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human integrin subtype αv  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology human integrin subtype αv
    RGDmix hydrogel enhances the secretion function of hAMSCs through the <t>integrin</t> <t>αv/PI3K/AKT</t> axis. (A) qRT-PCR confirmed the knockdown of integrin αv. (B) ELISA experiments showed that silencing integrin αv significantly reduces the expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel. (C) CCK-8 assay demonstrated that knockdown of integrin αv does not affect the proliferation of hAMSCs. (D) Representative photo images, (E) wound healing rates, and (F) Hematoxylin and eosin stained images of excisional wounds treated with different treatments. The inner diameters of the rubber rings were 8 mm. The blackarrow heads mark the edges of the original excision sites. (G) Quantification of epidermal thickness and the number of hair follicles (n = 5). (H) Expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel when the PI3K/AKT pathway was inhibited by LY294002 (n = 3). Significance levels were set at: * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control.
    Human Integrin Subtype αv, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 6130 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human integrin subtype αv/product/Santa Cruz Biotechnology
    Average 96 stars, based on 6130 article reviews
    human integrin subtype αv - by Bioz Stars, 2026-03
    96/100 stars

    Images

    1) Product Images from "RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells"

    Article Title: RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells

    Journal: Frontiers in Bioengineering and Biotechnology

    doi: 10.3389/fbioe.2024.1385931

    RGDmix hydrogel enhances the secretion function of hAMSCs through the integrin αv/PI3K/AKT axis. (A) qRT-PCR confirmed the knockdown of integrin αv. (B) ELISA experiments showed that silencing integrin αv significantly reduces the expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel. (C) CCK-8 assay demonstrated that knockdown of integrin αv does not affect the proliferation of hAMSCs. (D) Representative photo images, (E) wound healing rates, and (F) Hematoxylin and eosin stained images of excisional wounds treated with different treatments. The inner diameters of the rubber rings were 8 mm. The blackarrow heads mark the edges of the original excision sites. (G) Quantification of epidermal thickness and the number of hair follicles (n = 5). (H) Expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel when the PI3K/AKT pathway was inhibited by LY294002 (n = 3). Significance levels were set at: * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control.
    Figure Legend Snippet: RGDmix hydrogel enhances the secretion function of hAMSCs through the integrin αv/PI3K/AKT axis. (A) qRT-PCR confirmed the knockdown of integrin αv. (B) ELISA experiments showed that silencing integrin αv significantly reduces the expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel. (C) CCK-8 assay demonstrated that knockdown of integrin αv does not affect the proliferation of hAMSCs. (D) Representative photo images, (E) wound healing rates, and (F) Hematoxylin and eosin stained images of excisional wounds treated with different treatments. The inner diameters of the rubber rings were 8 mm. The blackarrow heads mark the edges of the original excision sites. (G) Quantification of epidermal thickness and the number of hair follicles (n = 5). (H) Expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel when the PI3K/AKT pathway was inhibited by LY294002 (n = 3). Significance levels were set at: * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control.

    Techniques Used: Quantitative RT-PCR, Knockdown, Enzyme-linked Immunosorbent Assay, Expressing, CCK-8 Assay, Staining, Control



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    Image Search Results


    RGDmix hydrogel enhances the secretion function of hAMSCs through the integrin αv/PI3K/AKT axis. (A) qRT-PCR confirmed the knockdown of integrin αv. (B) ELISA experiments showed that silencing integrin αv significantly reduces the expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel. (C) CCK-8 assay demonstrated that knockdown of integrin αv does not affect the proliferation of hAMSCs. (D) Representative photo images, (E) wound healing rates, and (F) Hematoxylin and eosin stained images of excisional wounds treated with different treatments. The inner diameters of the rubber rings were 8 mm. The blackarrow heads mark the edges of the original excision sites. (G) Quantification of epidermal thickness and the number of hair follicles (n = 5). (H) Expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel when the PI3K/AKT pathway was inhibited by LY294002 (n = 3). Significance levels were set at: * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control.

    Journal: Frontiers in Bioengineering and Biotechnology

    Article Title: RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells

    doi: 10.3389/fbioe.2024.1385931

    Figure Lengend Snippet: RGDmix hydrogel enhances the secretion function of hAMSCs through the integrin αv/PI3K/AKT axis. (A) qRT-PCR confirmed the knockdown of integrin αv. (B) ELISA experiments showed that silencing integrin αv significantly reduces the expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel. (C) CCK-8 assay demonstrated that knockdown of integrin αv does not affect the proliferation of hAMSCs. (D) Representative photo images, (E) wound healing rates, and (F) Hematoxylin and eosin stained images of excisional wounds treated with different treatments. The inner diameters of the rubber rings were 8 mm. The blackarrow heads mark the edges of the original excision sites. (G) Quantification of epidermal thickness and the number of hair follicles (n = 5). (H) Expression levels of growth factors VEGF and TGF-β in hAMSCs encapsulated in RGDmix hydrogel when the PI3K/AKT pathway was inhibited by LY294002 (n = 3). Significance levels were set at: * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control.

    Article Snippet: A total of forty picomoles of synthetic small interfering RNAs (siRNAs) were transfected into human amniotic mesenchymal stem cells (hAMSCs) in 24-well plates, targeting either the human integrin subtype αv (sc-29373, Santa Cruz) or a scrambled siRNA (sc-37007, Santa Cruz), following the manufacturer’s instructions.

    Techniques: Quantitative RT-PCR, Knockdown, Enzyme-linked Immunosorbent Assay, Expressing, CCK-8 Assay, Staining, Control

    Journal: eLife

    Article Title: Cas phosphorylation regulates focal adhesion assembly

    doi: 10.7554/eLife.90234

    Figure Lengend Snippet:

    Article Snippet: siITGAV , Santa Cruz, Cat: sc-29373 , sc-29373A: GCAUCUAUCUUGAAAGUAATT sc-29373B: CUGGUUUGAACGAUAGAAATT sc-29373C: GAAGCUGUGUAGUAUAUCATT.

    Techniques: Negative Control